The Myers-Briggs Type Indicator is frequently used by health professions and educational programs to address the diversity of personalities that exist. No systematic review of the literature or meta-analysis of its validity and reliability has occurred. This comprehensive literature search identified 221 potential studies, of which seven met our inclusion criteria. Four of the studies examined construct validity, but their varying methods did not permit pooling for meta-analysis. These studies agree that the instrument has reasonable construct validity. The three studies of test-retest reliability did allow a meta-analysis to be performed, albeit with caution due to substantial heterogeneity. Results indicate that the Extravert-Introvert, Sensing-Intuition, and Judging-Perceiving Subscales have satisfactory reliabilities of .75 or higher and that the Thinking-Feeling subscale has a reliability of .61. The majority of studies were conducted on college-age students; thus, the evidence to support the tool’s utility applies more to this group, and careful thought should be given when applying it to other individuals.